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鐘超

時間:2018-03-01瀏覽:10367設置

鐘超 Chao Zhong課題組介紹


Principal Investigator

鐘超 Chao Zhong,Assistant Professor, PI
Office Address:Room 210, Building 3, SPST, No. 393 Huaxia Middle Road, Pudong New Area, Shanghai

     上海市浦東新區華夏中路393號物質學院3號樓210室

E-mail:zhongchao@shanghaitech.edu.cn 


1997 to 2001, Bachelor of Engineering, Materials Science, Tianjin University;
2001 to 2004, Master degree in Materials Science, BUCT, Beijing;
2004 to 2009, Ph. D. in Biomedical Engineering, Cornell University;
2009 to 2011, Post-PhD, Department of MSE, University of Washington (Seattle);
2012 to 2014, Post-PhD, Department of EECS and Department of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of Technology;
2014-now PI & Assistant Professor, School of Physical Science and Technology, ShanghaiTech University;
2015  Shu Guang Plan Award, by Shanghai Municipal Education Commission


【人員招聘】實驗室誠招材料科學、化學、微生物學、生物化工以及合成生物學和納米技術等背景博士后1名。

【學生工作】長期歡迎生物、材料、化學、微生物等相關專業,對生物仿生材料及生物靈感納米材料感興趣的本科生,加入我們!


Research Interests


The Zhong lab at the Materials and Physical Biology Division in the School of Physical Science & Technology (SPST) aims to leverage the power of synthetic biology to develop an integrative bio-inspired molecular engineering (IBME) program, through which new materials, nanotechnologies and devices are created by adapting and applying the ways that living organisms develop and function. The ultimate goal of our research is to create stimuli-responsive, self-regenerating and life-enhancing functional materials and devices by integrating synthetic biology, microbial engineering, materials science, nanotechnology and modern manufacturing tools.

Our current research efforts are mainly focused on structural amyloids, emerging molecular materials with attributes including intrinsic self-assembly, ultra-stability, outstanding mechanical properties and tunable functionalities. Traditionally considered as mis-folded structures relevant to several neurodegenerative diseases in mammals, amyloids have been increasingly recognized as functional building blocks in organisms. For example, they are closely associated with the catalysis of melanin synthesis in mammalian melanosomes; they also constitute the primary structural proteins in bacterial biofilms, and functional components of underwater adhesives in marine species.

Taking inspiration from biology, our research program in harnessing functional amyloids for new biomaterials and bionanotechnologies comprise four main thrusts:

(1) Living Functional Materials;

(2) Bio-inspired Underwater Adhesives;

(3) Dynamic Complex Assemblies and Biofabrication;

(4) Biofilms-interfaced Biocatalysis & Artificial Photosynthesis.

Our research is committed to advancing the emerging field of synthetic biology and pushing new frontiers in biomaterials research and bionanotechnologies.


(1)      Living Functional Materials

Engineering Living Functional Materials with Synthetic Biology


Living functional materials represent a conceptually new type of materials that possess multifunctional, self-healing and adaptable properties, created and organized in a distributed, bottom-up and environmentally sustainable manner. By leveraging the power of synthetic biology, we are developing a programmable living functional material platform based on bacterial biofilm systems. 

Our current efforts along this line include: 

1) programming E. coli cells to organize inorganic nano-objects (NOs) in a spatiotemporally precise fashion with light-inducible and chemical-inducible gene circuits (X. Wang et al. Advanced Materials 2018); 

2) reprogramming Bacillus subtilis extracelluar matrix protein with new functional properties by genetically appending peptide domains or proteins to the amyloid-like protein TasA and leveraging the intrinsic protein secretion pathway (J. Huang et al. Nature Chemical Biology 2018). 

3) engineering Living cellular glues with tunable adhesion performances, environmental responsiveness, and autonomous repairing features. (C. Zhang et al. Materials Today 2019)  


As another example, we recently demonstrated that TasA variants having fusion proteins as large as 630 amino acids could be secreted and assemble into nanofiber networks, outperforming the previously reported E.coli CsgA system (60 amino acids). Furthermore, the living biofilms can be engineered with tunable viscoelastic properties and therefore are printable with three-dimensional (3D) printing technique. Notably, the bio-manufactured living functional biofilms remain alive and are able to sense chemical signals, serving as long-lasting environmentally responsive materials. The programmable living functional material platform promises new opportunities in biocatalysis, bioremediation, bioadhesion and biomedicine.  


(2)      Bio-inspired Underwater Adhesives


Stay Tuned !    :)


(3)      Complex Assemblies & Bio-fabrication

Biological materials and systems are replete with diverse self-assemblies, including both non-equilibrium and equilibrium systems. Self-assemblies constitute the basis of many complex supramolecular structures, providing extraordinary functional properties and playing important physiological roles for various molecular materials and biological machines. Characteristic of such biological self-assemblies is its dynamic, adaptive, and environmentally responsive nature, providing an unparalleled potential for a future repertoire of multifunctional materials and nanotechnologies. Inherent to many biological assemblies is the additional feature of self-replication: DNA from DNA; cells from cells.



In mimicking the diverse complex assembling systems in nature, we leveraged the intrinsic self-assembling propensity of the fused in sarcoma (FUS) low complexity (LC) domain, along with a modular genetic strategy, to construct tailor-designed supramolecular structures with variable functionalities. By finely controlling the sequential assemblies and associated assembly kinetics, our strategy was suitable for creating random copolymer-like, multi-block, and self-sorted supramolecular fibers that can either display distinct fluorescent functionalities or allow the spatially controlled assembly of nano-objects in structure-dependent fashions (ACS Nano 2017).


In E. coli biofilms, the outer membrane-localized amyloidgenic CsgB proteins could act as nucleators to guide the efficient polymerization of the major curli fiber subunit protein CsgA into amyloid fibers on the cell surface. Inspired by such nucleation-directed assembly of amyloid fibrils in bacterial biofilms, we developed a CsgB-decorated DNA origami (CB-origami) to mimic protein nucleators in Escherichia coli biofilm that direct curli polymerization. We showed that CB-origami directed curli subunit CsgA monomers to form oligomers and then accelerated fibril formation by increasing the proliferation rate of primary pathways. Fibrils growed either out from (departure mode) or towards the nucleators (arrival mode), implying two distinct roles of CsgB: as nucleation sites and as trap sites to capture growing nanofibrils in vicinity. This origami nucleator thus provided an in vitro platform for mechanistically probing molecular nucleation and controlling directional fibril polymerization for bionanotechnology.(Nature Communications 2019)



(4)      Biofilms-interfaced Biocatalysis & Artificial Photosynthesis

Stay Tuned !   :)



News

Oct 21-25 2019   Prof. Zhong has been invited to give a talk on “ Engineering Living Functional Materials with Synthetic Biology”  at the 2019 Cold Spring Harbor (CSH) Asia Conference on Synthetic Biology, to be held from Oct 21-25, 2019 in Suzhou, China.   (Corresponding link: https://www.csh-asia.org/2019meetings/synthesi.html)


Sep 9-12 2019   Prof. Zhong will present his research program as a Keynote Speaker on “Engineering Living Cellular Glues with Synthetic Biology” at the upcoming  2019 International Conference on Adhesion in Aqueous Media: From Biology to Synthetic Materials (AAM2019), to be held from Sep 9~12 in Dresden, Germany. (Corresponding link:  http://aam2019.org/?page_id=36)


Sep 6 2019   A research paper “Exploiting Mammalian Low Complexity Domains for Liquid-liquid Phase Separation Driven Underwater Adhesive Coatings” has been online in  Science Advances.


Sep 5 2019   A research paper “Patterned Amyloid Materials Integrating Robustness and Genetically Programmable Functionality” has been online in  Nano Letters.


Aug 26 2019   Prof. Zhong has been invited to give a Special Seminar on “Engineering Living Funtional Materials with Synthetic Biology” at the  Division of Chemistry and Chemical Engineering, Caltech.(corresponding link:  https://www.caltech.edu/campus-life-events/master-calendar/special-seminar-86467)


Aug 23 2019   A research paper “Biofilm Nanofibers-Coated Separator for Dendrite-Free Lithium Metal Anode and Ultrahigh-Rate Lithium Batteries” has been online in  ACS Applied Materials & Interfaces.


Aug 16 2019   Postdoc Xinyu Wang had been awarded the “Best Poster Award” by the organizer committee  the 5th synthetic biology young scholars forum at Tianjin.


July 17 2019   A research paper “Immobilization of functional nano-objects in living engineered bacterial biofilms for catalytic applications” has been accepted for publication in  National Science Review.


June 3 2019   Our work “Programmable and printable bacillus subtilis biofilms as engineered living materials” was highlighted by Physicsworld news: “3D printing and genetic engineering bring biofilms to life”.


May 27 2019   A research paper “Exploiting Mammalian Low Complexity Domains for Liquid-liquid Phase Separation Driven Underwater Adhesive Coatings” has been accepted for publication in  Science Advances. (Congrats to Mengkui Cui!)


May 31 2019   Congratulations to Dr. Xinyu Wang for successful defense of his Ph.D. dissertation (Xinyu is the first Ph.D. recipient from our IBME group)!


April 3-4 2019   Spring tour · Mogan Mountain


Mar 25 2019   Our work “Engineered Bacillus subtilis biofilms as living glues” was highlighted by Materials today news: “‘Living glue’ inspired by nature”.


Feb 15 2019   A research paper Genetic Design of Multi-domain Functional Amyloids: Insights into Self-assembly and Functional Properties has been accepted for publication in Chemical Science. (Congrats to Mengkui Cui, Qi Qi and T. Gurry!)


Feb 14 2019   A research paper Directing Curli Polymerization with DNA Origami Nucleators has been accepted for publication in Nature Communications(Congrats to Xiuhai Mao and Ke Li!)


Jan 21 2019   Our work “Engineered Bacillus subtilis biofilms as living glues” was highlighted by Materials today news:“Living glues, inspired by marine animals”.


Dec 20 2018   A research paper “Engineered Bacillus subtilis biofilms as living glues” has been accepted for publication in Materials Today. (Congrats to Chen Zhang, Jiaofang Huang and Jicong Zhang!)


Dec 6 2018   Prof. Zhong has been invited to give a talk titled “Engineering Living Functional Materials with Synthetic Biology” at the 2018 Synthetic Biology & “living” Soft Functional Matter, to be held at the campus of HKUST.  Thanks for the symposium organizer, Prof. Fei Sun, for the invitation!   


Dec 3 2018   Our recent paper titled “Programmable and Printable Bacillus subtilis Biofilms as Engineered Living Materials” has now been published online in Nature Chemical Biology. Congrats to our first co-authors, Dr. Jiaofang Huang, Suying Liu and Chen Zhang! (https://www.nature.com/articles/s41589-018-0169-2)


Nov 22 2018   Professor Zhong and Ph.D student Mengkui Cui attended the 3rd International Conference on Biological and Biomimetic Adhesives (ICBBA 2018) conference held in Haifa, Israel.  Prof. Zhong gave a talk titled “Engineering Living Cellular Glues with Synthetic Biology” and Mengkui made a poster presentation based on his Ph.D. work about “LLPS Driven Protein-based Underwater Adhesive Coatings” at the conference.


Oct 19 2018   Prof. Zhong gave an invited talk at the Young Scientist Forum of the AsiaNANO 2018, held in Qingdao, on our research progress about Living Functional Materials based on Engineered Bacterial Biofilms. Special thanks to the Forum Chair, Prof. Lele Li, for his invitation!  


Sep 27 2018   Prof. Zhong gave a talk titled “ Engineering Living Functional Materials with Synthetic Biology” at the 3rd Bioengineering & Translational Medicine Conference 2018, held in Boston. Really nice to meet new and old friends!    


Aug 30 2018   Prof. Zhong has been invited to give a lecture on our research about “Bacterial Biofilms Inspiration: from Programmable Amyloid Materials (PAMs) to Living Functional Materials (LFMs)” at 3M (Shanghai). Thanks Dr. Yu for his invitation and hosting!   


Aug 1 2018   Prof. Zhong, Xinyu Wang, Yingfeng Li, Mengkui Cui, Bolin An and Suying Liu attended the ACS Publication Symposium: Innovation in Materials Science, held at the ShanghaiTech campus.  Dr. Zhong has been selected by the symposium organizers to give a talk in the session of Materials for Biology on “Programmable Bacterial Biofilms as Living Functional Materials”.   


Aug 1 2018   Ph.D. Students, Yingfeng Li and Mengkui Cui, along with the other three attendee, had been awarded the “Best Poster Award” by the organizer committee at the ACS Publication Symposium: Innovation in Materials Science. Well done!  



June 2018   A farewell party for Chen Zhang, Susu Ren (graduation with a master degree) and undergraduate student Junwei Du, Special thanks for their contributions to IBME.


碩士生張琛與任蘇蘇和本科生杜君薇的告別歡送聚會——真人CS活動,IBME課題組感謝他們的貢獻并祝愿他們前程似景!


June 2018   A collaborative paper “Adhesive Bacterial Amyloid Nanofibers-Mediated Growth of Metal-Organic Frameworks on Diverse Polymeric Substrates” has been accepted for publication in Chemical Science.  (In collaboration with Tao Li @ ShanghaitTech).

與李濤老師的合作文章 “Adhesive Bacterial Amyloid Nanofibers-Mediated Growth of Metal-Organic Frameworks on Diverse Polymeric Substrates” 被 Chemical Science 接收。


學校新聞: http://www.shanghaitech.edu.cn/2018/0613/c1001a28110/page.htm

文章:http://pubs.rsc.org/en/content/articlelanding/2018/sc/c8sc01591k#!divAbstract


June 2018   Professor Zhong and three Ph.D students Yingfeng Li, Xinyu Wang and Bolin An attended the Gordon Research Conference (GRC) Bioinspired Multifunctional Dynamic Materials held in Switzerland(Les Diablerets Conference Center) from June 24 to 29, 2018. The three students made poster presentations, with the titles below:  

Yingfeng Li    “An amyloid-based fundamental building material with integrated genetically programmable functionality”

Xinyu Wang   “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control”

Bolin An         “Engineering Living Cellular Glues with Synthetic Biology”


鐘老師與博士生李穎風、王新宇和安柏霖參加高登研究會議,并作海報展示,受到同行的專家好評。


Prof. Zhong has been selected and recommended by the GRC Chair to present a short talk 'Engineering Living Cellular Glues with Synthetic Biology' at the Gordon Research Conference (GRC) Bioinspired Multifunctional Dynamic Materials.


鐘老師被Gordon Research Conference (GRC) Bioinspired Multifunctional Dynamic Materials會議主席邀請做題為'Engineering Living cellular glues with synthetic biology' short talk。


June 2018   Our work published in Advanced Materials has been highlighted in Advanced News. Check the VEDIO highlight following the link below.   

https://v.qq.com/x/page/n0690fjyn99.html


April 2018   Mr. Xinyu Wang, a senior Ph.D student, gave an oral presentation titled “Dynamic Bio-abiotic Hybrid Structures: Constructions and Applications” at the 7th Spring World Congress on Engineering and Technology (SCET 2018) on April 23 in Guilin, China. 

2013級博士生王新宇參加于4月23-24號在桂林召開的2018年第七屆春季國際工程與技術大會,并作題為“Dynamic Bio-abiotic Hybrid Structures: Constructions and Applications”報告。


April 2018   A communication paper titled “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control” has now been published online in Advanced Materials (selected as inside back cover and highlighted in video abstract on the official website!)

通訊文章 “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control”被在先進材料在線發表,并入選同期的內封面。該文章被先進材料編輯推薦在官方網站的視頻摘要(video abstract) 中進行重點介紹。

恭喜博士生王新宇、濮嘉華、安柏霖!

相關媒體報道:

學 校 新 聞:物質學院鐘超課題組開發出智能細菌,可時空調控無機納米材料的動態自組裝
澎 湃 新 聞:生物智造:中國科學家打一束光,讓細菌“打工”畫納米電路
CBG  資 訊:上??萍即髮W鐘超研究員團隊: 利用智能細菌時空調控無機納米材料的動態自組裝
材   料   牛:Adv. Mater.:用于動態組裝無機納米物體的編程單元
生 物 極 客:上科大鐘超課題組先進材料發表文章借助細菌實現時空納米材料組裝
長 江 日 報:用一束光讓細菌“干活” 未來你用的手機屏可能是細菌生產
中國科學報:一束光如何“馴化”大腸桿菌


April 2018   An invited review paper  “Emerging Paradigms for Synthetic Design of Functional Amyloids” has been accepted for publication in Journal of Molecular Biology, in the upcoming theme issue “functional amyloids”. (Congrats to Yanyi Wang, Jiahua Pu and Bolin An!).    

邀請綜述文章“Emerging Paradigms for Synthetic Design of Functional Amyloids”被Journal of Molecular Biology接收,恭喜王艷怡、濮嘉華和安柏霖!


Jan 2018   A communication paper titled “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control” has been accepted for publication in Advanced Materials. (Congrats to Xinyu Wang, Jiahua Pu and Bolin An!)

通訊文章 “Programming Cells for Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control” 被先進材料接受,恭喜博士生王新宇、濮嘉華和安柏霖!


Jan 2018   A collaborative paper “Programming Integrative Extracellular and Intracellular Biocatalysis for Rapid, Robust, and Recyclable Synthesis of Trehalose” has been accepted for publication in ACS Catalysis.  (In collaboration with Dr. Ling Jang and Dr. He Huang @Nanjing Tech).

與南京工大的合作文章 “Programming Integrative Extracellular and Intracellular Biocatalysis for Rapid, Robust, and Recyclable Synthesis of Trehalose” 被ACS Catalysis接收。(合作者:南京工業大學黃和教授與江凌博士)


Dec 2017   A farewell party for postdoc Xiuhai Mao and Mr. Tianxin Zhao (graduation with a master degree), Special thanks for their contributions to IBME.

毛秀海博士和趙田鑫的告別歡送聚會——火鍋歡送會, IBME課題組感謝他們的貢獻并祝愿他們前程似景!


Dec 2017   In collaboration with Professor Timothy K. Lu group at MIT, the Zhong group has recently been awarded “the MIT Greater China Fund for Innovation”. The funding supports collaborations between faculty at MIT and their counterparts in China, Hong Kong and Taiwan.


Nov 2017   Dr. Zhong’s expert comment on recent work published inAdvanced Materials Interfacesappeared in  “Inside Science”


Oct 2017   Dr. Zhong’s expert comment on recent work published in Science Advances appeared in Science News.


Oct 2017   崔孟奎、任蘇蘇及魏世操以“Natural and Bio-inspired Underwater Adhesives: Current Progress and New Perspectives”為題的文章,被 APL Materials接收。


Sept 2017   上??萍即髮W成功承辦第295期東方科技論壇。


July 2017   15級碩士研究生張?。ㄓ胰┰诘谌龑煤铣缮飳W青年學者論壇獲“優秀墻報獎”。


July 2017   博士研究生安柏霖與王新宇以“Diverse Supramolecular Nanofiber Networks Made by Complex Assembly of Functional Low-Complexity Domains”為題的文章,被 ACS NANO 接收。


Oct 2016   鐘超老師攜2014級本科生在2016年國際基因工程機器大賽(the International Genetically Engineered Machine Competition, iGEM)榮獲金獎。


Spring 2015   Dr. Zhong’s expert comment on recent work about underwater adhesives appeared in Nature Outlook.



Selected Publications

# Equal contribution,* Corresponding author


  1. L. Nie#, Y. Li#, S. Chen, K. Li, Y. Huang, Y. Zhu, Z. Sun, J. Zhang, Y. He, M. Cui, S. Wei, F. Qiu, C. Zhong*, and W. Liu*, Biofilm Nanofiber-Coated Separators for Dendrite-Free Lithium Metal Anode and Ultrahigh-Rate Lithium Batteries, ACS Appl. Mater. Interfaces, 2019, 11, 35, 32373-32380. DOI: 10.1021/acsami.9b08656

  2. Y. Li, C. Zhong* et al, Patterned Amyloid Materials Integrating Robustness and Genetically Programmable Functionality, Nano Letters, 2019. DOI: 10.1021/acs.nanolett.9b02324

  3. F. Tan#*, C. Chu#, J. Qi#, W. Li#, D. You, K. Li, X. Chen, W. Zhao, C. Cheng, X. Liu, Y. Qiao, B. Su, S. He, C. Zhong, H. Li*, R. Chai* & G. Zhong*, AAV-ie enables safe and efficient gene transfer to inner ear cells, Nature Communications, 2019, 10, 3733. DOI: 10.1038/s41467-019-11687-8

  4. X. Wang, C. Zhong* et al, Immobilization of Functional Nano-objects in Living Engineered Bacterial Biofilms for Catalytic Applications, National Science Review, nwz104, DOI: org/10.1093/nsr/nwz104.

  5. M. Cui, C. Zhong* et al, Exploiting Mammalian Low Complexity Domains for Liquid-liquid Phase Separation Driven Underwater Adhesive Coatings, Science Advances, 2019, 5(8), eaax3155.

  6. Y. Liu#, J. Qi#, X. Chen#, M. Tang#, C. Chu, W. Zhu, H. Li, C. Tian, G. Yang, C. Zhong, Y. Zhang, G. Ni, S. He*, R. Chai* and G. Zhong*, Critical role of spectrin in hearing development and deafness, Science Advances, 2019, 5(4), eaav7803. DOI: 10.1126/sciadv.aav7803

  7. X. Mao, K. Li, M. Liu, X. Wang, T. Zhao, B. An, M. Cui, Y. Li, J. Pu, J. Li, L. Wang, T. K. Lu, C. Fan*, and C. Zhong*. Directing Curli Polymerization with DNA Origami Nucleators. Nature communications 2019, 10, 1395. DOI: 10.1038/s41467-019-09369-6.

  8. M. Cui#,Q. Qi#, T. Gurry#, T. Zhao,B. An , J. Pu, X. Gui, A. Cheng, S. Zhang, D. Xun, M. Becce, F. Vangosa, C. Liu, T. K. Lu, C. Zhong* Genetic Design of Multi-domain Functional Amyloids: Insights into Self-assembly and Functional Properties, Chemical Science 2019, 10, 4004-4014. DOI: 10.1039/C9SC00208A.

  9. C. Zhang#, J. Huang#, J. Zhang#, S. Liu, M. Cui, B. An, X. Wang, J. Pu, T. Zhao, C. Fan, T. K. Lu, C. Zhong*, Engineered Bacillus subtilis biofilms as living glues, Materials Today 2019, 28, 40-48. DOI: 10.1016/j.mattod.2018.12.039.

  10. J. Huang#, S. Liu#, C. Zhang#, X. Wang, J. Pu, F. Ba, S. Xue, H. Ye, T. Zhao, K. Li, Y. Wang, J. Zhang, L. Wang, C. Fan, T. K. Lu, C. Zhong*, Programmable and Printable Bacillus subtilis Biofilms as Engineered Living Materials. Nature Chemical Biology 2019, 15, 34–41.

  11. X. Wang#, J. Pu#, B. An#, Y. Li,Y. Shang, Z. Ning, Y. Liu, F. Ba,J. Zhang,C. Zhong*,Programming cells for dynamic assembly of inorganic nano-objects with spatiotemporal control. Advanced Materials 2018, 30, 1705968. (Inside back cover & video abstract highlight)

  12. C. Zhang#Y. Li#, H. WangS. HeY. XuC. Zhong* and  T. Li*, Adhesive bacterial amyloid nanofiber-mediated growth of metal–organic frameworks on diverse polymeric substrates. Chemical Science 2018, 9, 5672–5678. 

  13. Y. Wang#, J. Hua#, B. An#, T. K. Lu*, C. Zhong*, Emerging Paradigms for Synthetic Design of Functional Amyloids, Journal of Molecular Biology 2018 in press, (Invited review in theme issue “functional amyloids”).

  14. L. Jiang, X. Song, Y. Li, Q. Xu, J. Pu, H. Huang*, and C. Zhong*, Programming integrative extracellular and intracellular biocatalysis for rapid, robust, and recyclable synthesis of trehalose. ACS Catalysis 2018, 8, 1837?1842.

  15. Q. Qi, T. Zhao, B. An, X. Liu, C. Zhong*, Self-assembly and morphological characterization of two-component functional amyloid proteins, Chinese Chemical Letters, 2017, 28(5), 1062-1068. DOI: 10.1016/j.cclet.2016.12.008

  16. B. An#, X. Wang#,M. Cui#, X. GuiX. MaoY. LiuK. LiC. ChuJ. PuS. RenY. WangG. ZhongT. K. LuC. Liu, and C. Zhong*, Diverse supramolecular nanofiber networks assembled by functional low-complexity domains. ACS Nano 2017, 11 (7), 6985–6995.

  17. M. Cui#, S. Ren#, S. Wei#, C. Sun, C. Zhong*, Natural and bio-inspired underwater adhesives: current progress and new perspectives. APL Materials 2017, 5, 116102. (Invited review). 

  18. X. Y. Wang #, Y. F. Li #, C. Zhong*, Amyloid-directed assembly of nanostructures and functional devices for bionanoelectronics. Journal of Materials Chemistry B. 2015, 3, 4953-4958. (Invited review). 


  19. Before Joining ShanghaiTech

  20. C. Zhong, T. K. Lu et al, Strong underwater adhesives made by self-assembling multi-protein nanofibres. Nature Nanotechnology 2014, 10, 858-866. (Highlighted in MIT News, the Scientist, Science Daily, Materials Today, MRS website and others)    

  21. C. Zhong, Y. X. Deng, A. Kapetanovic, M. Rolandi, A polysaccharide bioprotonic field-effect transistor. Nature Communications 2011, 2, 476. (Highlighted by MIT Tech Review, IEEE Spectrum, MRS website and others). 

  22. C. Zhong, A.Kapetanovic, Y. X. Deng, M. Rolandi, A chitin nanofiber ink for airbrushing, replica molding and microcontact printing of self-assembled marco-, micro- and nanostructures. Advanced Materials 2011, 23, 4776-4781. (Inside cover feature).

  23. C. Zhong, C.C.Chu, Biomimetic mineralization of acid polysaccharide-based hydrogels: Towards porous 3-dimensional bone-like biocomposites. Journal of Materials Chemistry 2012, 22, 6080-6087. (Highlighted in Biomimetic Materials Collection on RSC Biomaterials Science Blog).

  24. C. Zhong, C. C. Chu et al., Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-PEGDA hybrid hydrogels. Acta Biomaterialia, 2010, 6, 3908-3918.

  25. C. Zhong, A. Cooper, A. Kapetanovic, M. Zhang, M. Rolandi, A facile bottom-up route to self-assembled biogenic chitin nanofibers. Soft Matter 2010, 6, 5298-5301. 

  26. C. Zhong, C. C. Chu, On the origin of amorphous cores in biomimetic calcium carbonate spherulites: new insights into spherulitic crystallization. Crystal Growth and Design 2010, 10, 5043-5049.

  27. C. Zhong, C. C. Chu, Acid polysaccharide-induced amorphous calcium carbonate (ACC) films: colloidal nanoparticle self-organization process. Langmuir 2009, 25, 3045–3049.

  28. A. Y. Chen #, C. Zhong #, T. K. Lu, Engineering living functional materials. ACS Synthetic Biology 2015, 4, 8-11 (Invited Perspective paper).



Group Photos


Group Members

黃嬌芳 助理研究員

Living Functional Materials
Microbial Metabolism and Regulation

郵箱:huangjf@shanghaitech.edu.cn

黃園園 博士后

Engineering light-powered smart living underwater glues via synthetic biology strategies

郵箱:huangyy@shanghaitech.edu.cn

安柏霖 博士

Living cellular glues Self-assemble Supramolecular Nanostructures

 HFUT

郵箱:anbl@shanghaitech.edu.cn

崔孟奎 博士

Bio-inspired Underwater Adhesives
Intermolecular Interaction

 SEU

郵箱:cuimk@shanghaitech.edu.cn

李柯 博士

Synthetic Biology Functional Biofilms 
Bio-minerlization

 NEFU

郵箱:like@shanghaitech.edu.cn

李穎風 博士

Microfabrication Bionanotechnology
Synthetic Biology

 TJU

郵箱:liyf@shanghaitech.edu.cn

劉蘇瑩 博士

Living Functional Materials
Microbial Metabolism and Regulation

 SPU

郵箱:liusy @shanghaitech.edu.cn

濮嘉華 博士

Artificial photosynthesis

 ECNU

郵箱:pujh@shanghaitech.edu.cn

王新宇 博士

Bio-inorganic Interface
Biocatalysis

 ZZU

郵箱:wangxy@shanghaitech.edu.cn

王艷怡 博士

Self-assembling Supramolecular Nanostructures

 HNU

郵箱:wangyy1@shanghaitech.edu.cn

魏世操 博士

Functional Biofilms

 CPU

郵箱:weisc@shanghaitech.edu.cn


蔣曉宇 碩士

Underwater adhesive

 NJTech

郵箱:jiangxy1@shanghaitech.edu.cn


張繼聰 碩士

Artificial photosynthesis--CO2 reduction

 UJN

郵箱:zhangjc@shanghaitech.edu.cn

劉奕 碩士

Implantable biomedical materials based on ionic conduction

 ShanghaiTech

郵箱:liuyi@shanghaitech.edu.cn

張思雨 碩士

Stay Tuned ! :)

 ZSTU

郵箱:zhangsy2@shanghaitech.edu.cn

巴方 碩士

Artificial photosynthesis

 ShanghaiTech

郵箱:bafang@shanghaitech.edu.cn


謝余 本科生

Functional Protein & Supermolecular Structure

 ShanghaiTech

郵箱:xieyu@shanghaitech.edu.cn

尋東民 本科生

light-switchable platform based on self-assembling amyloid protein

 ShanghaiTech

郵箱:xundm@shanghaitech.edu.cn

辛美玲 技術員

郵箱:xinml@shanghaitech.edu.cn


Alumni
2016屆碩士锜琦



2017屆碩士趙田鑫



博士后毛秀海上海交通大學分子醫學研究院助理研究員
2018屆碩士張琛洛桑聯邦理工學院生物技術與生物工程博士
2018屆碩士任蘇蘇



2018屆本科生杜君微圣路易斯華盛頓大學材料科學與工程博士
2019屆本科生謝余加州大學圣地亞哥分校納米工程博士



Job Openings
  1. 【人員招聘】實驗室誠招材料科學化學,微生物學,生物化工以及合成生物學和納米技術等背景博士后1名。

  2. 【學生工作】長期歡迎生物、材料、化學、微生物等相關專業,對生物仿生材料及生物靈感納米材料感興趣的本科生,加入我們!


Seminar

20190711 Synthetic Biology for Enhanced Protein Functions and Animal Performance

Qing Sun

Assistant Professor

Department of Chemical Engineering, Texas A&M University








20190702 Decode and reprogram the yeast genome            

戴俊彪

研究員

中國科學院深圳先進技術研究院








20190611 Sequence-Specific Peptoids for Self-Assembly and Biointerfacial Applications

Prof. King Hang Aaron Lau


University of Strathclyde








20190607 Talking to Cells: Biomolecular Engineering for Non-Invasive Imaging and Control of Cellular Function

Prof. Mikhail G. Shapiro


California Institute of Technology








20190527 合成生物學與應用

元英進

教授,副校長

天津大學








20190422 蛋白質的可控聚集與界面粘附

楊鵬

教授

陜西師范大學








20190419 智能型納米器件用于精準診療

李樂樂

研究員

國家納米科學中心








20190416 數據驅動的蛋白質設計方法

劉海燕

教授

中國科學技術大學生命科學學院








20190410 Antimicrobial Amino Acid Polymers as Synthetic Mimics of Host Defense Peptide

Runhui Liu (劉潤輝)


East China University of Science and Technology (華東理工大學)








20190103 Synthetic Biology: Pushing the New Frontiers of Materials Science and Medical Therapeutics

Towards efficient biosynthesis of anti-tumor ganoderic acids (GAs)

Prof. Han Xiso

Shanghai Jiao Tong University


Unleashing Chemical Power from Protein Sequence Space for Material Design

Prof. Fei Sun

Hong Kong University of Science and Technology


Versatile biomanufacturing through stimulus responsive cell-material feedback

Prof. Zhuojun Dai

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences


Precision controlled designer cells for biomedical applications

Prof. Haifeng Ye

East China Narmol University


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