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左智偉

時間:2018-03-01瀏覽:17014設置

左智偉課題組介紹


課題組長
左智偉,助理教授、研究員
通訊地址:3號樓405
電子郵件:zuozhw@@shanghaitech.edu.cn 
2003年至2007年就讀于南京大學化學化工學院,獲化學學士學位;2007年至2012年就讀于中科院上海有機化學研究所,獲得有機化學博士學位,師從馬大為研究員,主要從事天然產物全合成研究; 2013年至2015年在普林斯頓大學化學系從事博士后研究,師從David W. C. MacMillan教授,專注于發展高效的光催化合成方法學。
2015年9月加入上??萍即髮W物質學院擔任助理教授和博導。

Dr. Zhiwei Zuo received a bachelor’s degree in chemistry from Nanjing University at 2007. Then he went on to pursue his PhD in organic synthesis at Shanghai Institute of Organic Chemistry, CAS. From 2017 to 2012, he worked on the total synthesis of the communesin alkaloids under the supervision of Prof. Dawei Ma. In 2013, he joined the MacMillan group at Princeton University as a postdoctoral researcher. Under the guidance of Prof. Dave MacMillan, he started to learn about photoredox catalysis and pursued the development of photocatalytic decarboxylation transformations. He joined the School of Physical Science and Technology at ShanghaiTech University in the autumn of 2015, where his group’s work has focused on the development of sustainable photocatalytic systems.

研究介紹

光促有機反應是通過催化劑將光能轉化為化學能,進而實現反應底物在溫和條件下的高選擇性、高效率轉化。我們致力于發掘廉價金屬的光化學性質,開發新型催化劑,將廉價易得的原料高效轉化為高附加值產品。我們率先發展了 LMCT 催化模式 ( LMCT Catalysis ),通過金屬復合物的光促配體到金屬的電子躍遷途徑,利用光能來高效實現有機分子的氧化。利用這一高效催化模式,我們不僅研究有機分子中的碳氫鍵、碳碳鍵官能團化方法,而且更加深入探索能源分子如甲烷、二氧化碳等的催化活化與利用,為綠色能源化工發展提供新思路。在成功開發這些高效合成方法的基礎上,我們將進一步展開對高活性天然產物、藥物分子的合成;同時也將探索小分子試劑與蛋白質等大分子的偶聯反應,開發新型光催化生物正交反應。


Photoredox catalysis has emerged as a powerful platform for the direct activation and functionalization of organic molecules via open-shell pathways. Central to this approach is the photoexcited metal-to-ligand charge transfer (MLCT) of metal–polypyridyl complex that can convert light energy into chemical potential energy for single electron transfer (SET) oxidations or reductions. Ligand-to-metal charge transfer (LMCT) is a mechanistically distinct and synthetically underinvestigated excitation process, which promotes homolysis of a metal–ligand bond to generate ligand-based radical intermediates. We have successfully utilized light energy to generate various energetically challenging alkoxy radicals from simple alcohols, via a coordination-LMCT excitation-homolysis sequence, a photoredox mode we coined LMCT catalysis. This mode enables targeted oxidation to occur only at the transiently coordinated functional group, and more importantly, facilitates the development of more affordable and sustainable photocatalytic systems. This approach has enabled us to achieve selective activation of alcohol feedstocks through cerium photocatalysis under mild and ecological conditions, to develop alkoxy radical mediated skeletal rearrangements of cyclic alcohols and remote C–H functionalization of alcohols. With the synergistic merger of LMCT and HAT catalysis, the intrinsically inert C–H bond in methane could be homolytically cleaved by HAT process with alkoxy radicals at room temperature to generate highly reactive methyl radical, offering new opportunities for the direct functionalizations of methane.                      




發表文章

http://orcid.org/0000-0002-3361-3220

Independent Publications:

  1. Anhua Hu?, Jing-Jing Guo?,Hui Pan, Zhiwei Zuo*, “Selective functionalization of methane, ethane, and higher alkanes by cerium photocatalysis” Science 2018, 361, 668.

  1. Anhua Hu?, Yilin Chen?, Jing-Jing Guo, Na Yu, Qing An, and Zhiwei Zuo*, “Cerium-Catalyzed Formal Cycloaddition of Cycloalkanols with Alkenes through Dual Photoexcitation.”, J. Am. Chem. Soc. 2018140, 13580.

  1. Anhua Hu?, Jing-Jing Guo?,Hui Pan, Haoming Tang, Zhaobo Gao, Zhiwei Zuo*, “?-Selective functionalization of alkanols enabled by visible-light-induced ligand-to-metal charge transfer” J. Am. Chem. Soc. 2018, 140, 1612.

  1. Jing-Jing Guo?, Anhua Hu?, Yiling Chen, Jianfeng Sun, Haoming Tang, Zhiwei Zuo*, “Photocatalytic C?C Bond Cleavage and Amination of Cycloalkanols by Cerium(III) Chloride Complex”, Angew. Chem. Int. Ed. 2016, 55, 15319.

PhD & Postdoc publications:

  1. Zhiwei Zuo?, Huan Cong?, Wei Li, Junwon Choi, Gregory C. Fu, David W. C. MacMillan “Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis”, J. Am. Chem. Soc. 2016, 138, 1832.

  2. Weiwei Zi, Zhiwei Zuo, Dawei Ma. Acc. Chem. Res. 2015,48, 702.

  3. Lingling Chu, Chisa Ohta, Zhiwei Zuo, David W. C. MacMillanJ. Am. Chem. Soc. 2014,136, 10886.

  4. Zhiwei Zuo, Derek Ahneman, Lingling Chu, Jack Terrett, Abigail G. Doyle and David W. C. MacMillan “Merging photoredox with nickel catalysis: Coupling of α-Carboxyl sp3-Carbons with Aryl Halides”, Science 2014, 345, 437.

  5. Zhiwei Zuo and David W. C. MacMillan. “Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore”, J. Am. Chem. Soc. 2014, 136, 5257.

  6. Zhiwei Zuoand Dawei Ma. “Enantioselective Total Syntheses of Communesins A and B”, Angew. Chem. Int. Ed. 2011, 50, 12008.

  7. Zhiwei Zuo and Dawei Ma. “Synthetic Studies toward Communesins”, Isr. J. Chem. 2011, 51, 434.

  8. Zhiwei Zuo, Weiqing Xie and Dawei Ma. “Total Synthesis and Absolute Stereochemical Assignment of (?)-Communesin F”, J. Am. Chem. Soc. 2010, 132, 13226.



本組成員

常亮 博士后

2011年于中國藥科大學獲得學士學位;
2018年于索邦大學獲得博士學位,博士期間主要從事綠色化學相關研究工作。

郵箱:changliang@shanghaitech.edu.cn

郭婧婧

2009年于蘭州大學獲得學士學位;
2014年于蘭州大學獲得博士學位,博士期間主要從事天然產物全合成相關工作。

郵箱:guojj@shanghaitech.edu.cn

胡安華

2009年于蘭州大學獲得學士學位;2014年于中國科學院上海有機化學研究所獲得博士學位,博士期間主要從事天然產物全合成相關工作。

郵箱:huah@shanghaitech.edu.cn

陳奕霖 (G5)

出生于遼寧撫順。本科畢業于大連海事大學,獲工學學士學位。

郵箱:chenyl@shanghaitech.edu.cn

湯昊明(G4)

出生于安徽淮北。本科畢業于中國科學技術大學,獲理學學士學位。

郵箱:tanghm@shanghaitech.edu.cn

張凱寧(G4)

出生于湖南邵東。本科畢業于中國礦業大學,獲理學學士學位。

郵箱:zhangkn@shanghaitech.edu.cn

潘輝(G3)

出生于江蘇宿遷。本科畢業于蘭州大學,獲理學學士學位。

郵箱:panhui@shanghaitech.edu.cn

孫麒(G3)

出生于江蘇常州。本科畢業于中國藥科大學,獲理學學士學位。

郵箱:sunqi@shanghaitech.edu.cn

安慶 (G2)

出生于甘肅慶陽,本科畢業于吉林大學,獲理學學士學位。

郵箱:anqing@shanghaitech.edu.cn

杜建波(G2)

出生于河北石家莊。本科畢業于北京理工大學,獲理學學士學位。

郵箱:dujb@shanghaitech.edu.cn

王鑫(G1)

出生于陜西渭南。本科畢業于蘭州大學,獲理學學士學位。

郵箱:wangxin2@shanghaitech.edu.cn

賀旭(G1)

出生于甘肅定西。本科畢業于蘭州大學,獲理學學士學位。

郵箱:hexu@shanghaitech.edu.cn

馬越(G1)

出生于遼寧撫順。本科畢業于沈陽藥科大學,獲理學學士學位。

郵箱:mayue@shanghaitech.edu.cn

楊小坤(G1)

出生于山東濰坊。本科畢業于青島科技大學,獲工學學士學位。

郵箱:yangxk@shanghaitech.edu.cn

張謝旸(UG3)

出生于上海市。本科就讀于上??萍即髮W。

郵箱:zhangxy2@shanghaitech.edu.cn

劉浩琳(UG1)

出生于山東青島。本科就讀于上??萍即髮W。

郵箱:liuhl2@shanghaitech.edu.cn


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